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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF6
All Species:
13.94
Human Site:
T619
Identified Species:
30.67
UniProt:
Q9H4E7
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H4E7
NP_071330.3
631
73910
T619
E
A
P
A
P
A
S
T
P
Q
E
D
K
L
D
Chimpanzee
Pan troglodytes
XP_518424
631
73898
T619
E
A
P
A
P
A
S
T
P
Q
E
D
K
L
D
Rhesus Macaque
Macaca mulatta
XP_001116665
631
73997
T619
E
A
P
V
P
A
S
T
P
Q
E
D
K
L
D
Dog
Lupus familis
XP_542503
666
77164
W659
L
E
E
R
E
K
S
W
K
G
K
K
S
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C2K1
630
73435
S619
T
P
I
L
A
L
A
S
Q
E
E
K
L
D
P
Rat
Rattus norvegicus
XP_228031
630
73547
S619
T
P
I
L
A
L
A
S
Q
E
E
K
L
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510112
591
69266
A583
K
N
W
K
G
K
R
A
P
S
N
S
E
S
Q
Chicken
Gallus gallus
Q5F4B2
586
68393
W578
L
E
Q
R
Q
K
S
W
K
G
K
K
A
S
S
Frog
Xenopus laevis
Q6PA69
596
70153
T585
T
L
D
G
K
D
H
T
H
P
A
G
E
H
V
Zebra Danio
Brachydanio rerio
Q7SYB5
612
72072
T605
E
A
D
R
R
L
S
T
N
G
Q
M
E
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790206
454
53839
E447
E
D
R
A
R
T
Q
E
E
I
D
Q
L
T
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.8
41.4
N.A.
92.5
92.8
N.A.
44.2
44
60.3
67
N.A.
N.A.
N.A.
N.A.
26.9
Protein Similarity:
100
99.6
99.2
60.2
N.A.
95.4
95.8
N.A.
63.8
64.8
77.3
80.5
N.A.
N.A.
N.A.
N.A.
45
P-Site Identity:
100
100
93.3
6.6
N.A.
6.6
6.6
N.A.
6.6
6.6
6.6
26.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
20
N.A.
26.6
26.6
N.A.
20
13.3
13.3
46.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
37
0
28
19
28
19
10
0
0
10
0
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
19
0
0
10
0
0
0
0
10
28
0
19
28
% D
% Glu:
46
19
10
0
10
0
0
10
10
19
46
0
28
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
10
0
0
0
0
28
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
10
0
10
0
0
0
0
10
0
% H
% Ile:
0
0
19
0
0
0
0
0
0
10
0
0
0
10
10
% I
% Lys:
10
0
0
10
10
28
0
0
19
0
19
37
28
0
0
% K
% Leu:
19
10
0
19
0
28
0
0
0
0
0
0
28
28
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
10
0
10
0
0
0
0
% N
% Pro:
0
19
28
0
28
0
0
0
37
10
0
0
0
0
19
% P
% Gln:
0
0
10
0
10
0
10
0
19
28
10
10
0
0
10
% Q
% Arg:
0
0
10
28
19
0
10
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
55
19
0
10
0
10
10
19
10
% S
% Thr:
28
0
0
0
0
10
0
46
0
0
0
0
0
19
0
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
10
0
0
0
0
19
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _